AtremoPlus enhances Norepinephrine/Noradrenaline levels ! But why is this so important?

AtremoPlus significantly increases Noradrenaline/Norepinephrine levels!

Norepinephrine, also known as noradrenaline, is investigated by the scientific community and shown to play a crucial role in many body functions, including motor and cognitive functions and protective repair work.

However, several questions remain: 
1. Why is noradrenaline/ norepinephrine widely ignored in Parkinson’s disease and Alzheimer’s disease communities? and,

2. Why is this crucial component not more primarily developed as a significant complementary option to L-dopa to optimize brain- and motor functions? and,  

3. Which food supplements have proven track records and repetitive analysis proving that they can actually increase noradrenaline/norepinephrine levels? 

AtremoPlus has a proven track record in noradrenaline/ norepinephrine increase, as basal levels and increase have been repeatedly measured in human clinical trials with the natural product. The outcomes are outstanding!

The natural product based on Vicia Faba extracts (not the beans but structural parts of the plant) showed a tremendous increase in noradrenaline levels after its intake. A more than 25% increase could be observed compared to the basal levels after one hour of intake!

AtremoPlus has a high and normalized content in natural L-Dopa and is well tolerated without any observed side effects during clinical trials.
In addition, the increased noradrenaline levels may play a crucial role in our clients’ positive feedback, including in our recent survey. Users report indeed tremendous improvements in many areas, enhancing mental, emotional, and motor well-being in their daily lives. 

But why is noradrenaline so important? 

Noradrenaline/norepinephrine serves several crucial functions in the human body:

1. Neurotransmission: Noradrenaline acts as a neurotransmitter in the sympathetic nervous system, facilitating communication between nerve cells. It’s involved in various brain functions, including attention, focus, and arousal.

2. Mood Regulation: It affects mood by modulating the activity of other brain chemicals. It contributes to feelings of alertness, wakefulness, motivation, and positive mood. Low levels of norepinephrine have been associated with conditions like depression, anxiety, and low energy levels. 

3. Memory Formation: Some research suggests that noradrenaline also plays a key role in memory formation and learning processes.

4. Modulation of Synaptic Plasticity: Noradrenaline can influence synaptic plasticity, which is crucial for forming and storing memories. It can modify the strength of connections between neurons, facilitating the creation of new neural circuits associated with memory.

5. Interaction with Other Neurotransmitters: Noradrenaline interacts with other neurotransmitters like dopamine and glutamate, affecting neuronal signaling pathways that are essential for memory consolidation and retrieval.

Overall, noradrenaline plays a multifaceted role in the body, impacting various physiological processes and influencing both physical and mental functions.

What specific role can noradrenaline play in Parkinson’s? 

Norepinephrine’s role in motor disorders is primarily linked to its influence on brain circuits that regulate movement and coordination. Here are some aspects of its involvement:

1. Motor control: Norepinephrine/noradrenaline plays a modulatory role in the basal ganglia, a brain region involved in motor control. In Parkinson’s disease, the loss of dopamine-producing cells affects not only dopamine but also norepinephrine pathways. Norepinephrine has been suggested to compensate for dopamine loss, partially modulating motor symptoms like bradykinesia (slowness of movement) and rigidity.

2. Tremors and Dyskinesias: Changes in norepinephrine levels or its modulation of other neurotransmitter systems might influence tremors and dyskinesias. However, the specific mechanisms are complex and not fully understood.

3. Norepinephrine Systems: The locus coeruleus, a brain region rich in norepinephrine-producing neurons, projects to areas involved in motor control. Dysregulation or changes in the activity of the locus coeruleus-norepinephrine system might contribute to motor dysfunction in some neurological conditions.

4. Role in Movement Planning: Norepinephrine, alongside other neurotransmitters, might be involved in the planning and execution of motor tasks. Its role in attention, arousal, and cognitive processes related to motor planning could indirectly impact movement in motor disorders.

Could noradrenaline even have protective and neurotrophic effects?

Norepinephrine has also garnered attention for its potential role in neuroprotection. While its specific neuroprotective mechanisms are not fully elucidated, several studies suggest its involvement in safeguarding neurons from damage and promoting their survival:

1. Anti-Inflammatory Effects: Noradrenaline/ Norepinephrine can modulate the immune response in the brain by regulating the activity of microglia, the brain’s immune cells. It might exert anti-inflammatory effects that could protect neurons from inflammatory damage associated with various neurodegenerative conditions.

2. Neurotrophic Effects: Norepinephrine may promote the release of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). These factors play critical roles in neuronal survival, growth, and repair, potentially offering protection against neurodegeneration. 

3. Regulation of Cerebral Blood Flow: Norepinephrine influences cerebral blood flow by modulating blood vessel constriction and dilation. Maintaining adequate blood flow to the brain is crucial for delivering oxygen and nutrients, which are vital for neuronal health.

4. Neuromodulation: Norepinephrine acts as a neuromodulator, regulating the activity of various brain regions. Its modulation of neuronal firing patterns and synaptic plasticity might contribute to neuronal resilience against damage.

Understanding these potential neuroprotective roles of norepinephrine has spurred interest in exploring its therapeutic potential for neurodegenerative diseases. Researchers are investigating ways to modulate norepinephrine pathways pharmacologically to potentially mitigate neuronal damage and slow disease progression. However, further studies are necessary to determine the precise mechanisms and develop targeted therapies effectively leveraging norepinephrine for neuroprotection in various neurological conditions.