2 – Brain Plasticity Through the Law of HormesisNow that we have seen how you can take action and provide your body with the essential active ingredients to protect your stem cell reservoirs and promote their activation, let’s move on to the next step. The second key element for creating new neurons and synapses—and thus strengthening your brain plasticity—relies on your physical and mental activity. By taking action, you can shape new cerebral realities.
Passively enduring the situation is a stance to avoid. It is essential to signal to your brain and body that they need new neural resources to carry out various cognitive and physical activities.
To achieve this, it is crucial to gradually step out of your comfort zone by leveraging the law of Hormesis, a fascinating phenomenon that shows how moderate exposure to stress or challenge can strengthen an organism’s capabilities and improve its adaptation. This principle also applies to the brain: when stimulated in a controlled manner, it does not merely adapt but also enhances its protection and regeneration mechanisms.
Applying the principle of Hormesis means pushing your personal limits, briefly stepping out of your comfort zone, and then allowing time for recovery. When we reach our limits, the body strengthens itself to adapt. In the context of Parkinson’s disease, this concept is closely linked to brain plasticity, the brain’s ability to create new neural connections, compensate for lost functions, and adapt to new situations.
Activities such as physical exercise, cognitive learning, and motor challenges can trigger this plasticity by activating the body’s natural repair mechanisms and promoting the production of new neurons. However, for this stimulation to be beneficial, it must maintain a balance. Excessive or prolonged stress can have the opposite effect, depleting the brain’s reserves. The idea is to progress at your own pace, gradually increasing the difficulty of tasks or exercises to stimulate the brain and body’s resilience and adaptability while avoiding burnout. Listen to what brings you joy, introduce your body to new ways of acting, and remain attentive to what feels good for it. By applying the law of Hormesis, the brain should not be seen as a fixed organ but rather as a living and dynamic entity, capable of adapting and strengthening itself in response to appropriate challenges.
The concept of brain plasticity can become a powerful driver, not only to slow down the loss of function but also to regain certain abilities. With targeted stimulation, a favorable environment, and a balanced approach, it is possible to fully harness this potential for adaptation and regeneration. No matter the scale of progress achieved, every step forward matters—whether as simple as regaining the ability to dress independently, resuming a sport, gardening, improving concentration on a sudoku, or sharing a game of catch with grandchildren, all the way to “climbing a glacier in the Alps, accompanied by my daughter, a rollator, and caring individuals.” (Testimony from one of our clients who has been taking AtremoPlus for several years and was previously often in a wheelchair). One particularly interesting point is that many AtremoPlus users report feeling a significant energy boost, making it easier and more motivating to initiate activities.
It is true that to challenge ourselves and fully benefit from the law of Hormesis, we need energy. This frequent energy surge observed in AtremoPlus users can be explained not only by an increase in dopamine levels in the brain but also by a significant rise in norepinephrine levels (on average +26%) (see newsletter issue number 24 below for more details). This increase in norepinephrine promotes better concentration, increased energy, improved mood and well-being, while also helping to reduce stress and enhance sleep quality. In essence, the law of Hormesis answers a crucial question for regaining lost ground and awakening your reservoirs of dormant stem cells: 👉 Why should your body develop new abilities or recover lost ones if you don’t give it a reason to do so? 👉 Why would it activate these capacities if you don’t demonstrate—through physical and/or cognitive exercises—that this demand is real and that you genuinely want to progress in this area? It is essential to find your own methods and identify how you can challenge your brain to signal the need for new neurons and encourage its adaptation. To provide you with even more concrete ideas on how to stimulate the awakening of dormant stem cells and optimize brain plasticity, our next newsletter will be entirely dedicated to exercises and methods—often fun and enjoyable—accompanied by scientific studies demonstrating their benefits. And the good news is, there will be something for everyone! Some activities have been proven effective with minimal effort and are perfectly suitable even for very elderly individuals. Of course, this newsletter is not intended to provide medical advice. For any medical concerns, please consult your healthcare professional. | 
