I. The Standard Dosage of AtremoPlus
To establish a standardized method, it was essential to ensure reliable and consistent dosing. That’s why we implemented a process to standardize AtremoPlus in terms of L-Dopa content.
While nature offers many advantages, including excellent tolerance of its active compounds, it also presents certain variability: each cultivated plant may contain slightly different levels of L-Dopa. However, for many people using AtremoPlus, including those with Parkinson’s, a safe and regular dosage is crucial. Neurologists also generally appreciate this consistency, as it helps them better support their patients in using AtremoPlus.
Our process homogenizes different batches of powder to guarantee a standardized L-Dopa content of 21.5 mg per gram. Each box of AtremoPlus also includes a scoop, specifically designed for precise dosing adapted to individual needs.
What is the standard dosage?
The recommended daily dosage of AtremoPlus ranges between 5 and 20 g and depends on various factors.
Most of our clients take 10 g per day (two scoops in the morning on an empty stomach or during the morning and two more scoops in the afternoon).
The minimum dosage to feel effects is 5 g per day (two scoops).
One scoop contains 2.5 g of powder, equivalent to approximately 54 mg of L-Dopa.
👉 Important: We occasionally hear feedback from people who report insufficient effects. In many cases, we find they are taking only 2.5 g per day (one scoop), a quantity that may indeed be insufficient to produce noticeable effects.
To maximize effects, it is recommended to take the powder on an empty stomach to avoid interaction with food. During the day, it’s preferable to take AtremoPlus before a meal rather than after. If the first dose of the day wasn’t taken before breakfast, we recommend taking it around 10–11 a.m., and the second dose between 3–6 p.m., depending on lunch and dinner. In other words, it’s best to wait 2–3 hours after a meal to take it on an empty stomach.
This approach ensures optimal absorption and allows users to fully benefit from AtremoPlus. Some individuals also take AtremoPlus at the very beginning of breakfast or just before lunch with good results. Observing oneself and keeping the routine flexible is key to integrating AtremoPlus into daily life smoothly.
II. Clinical Trial Results on Dosage
We are not authorized to comment on individual medical treatments.
However, generally speaking, most of our clients take both their Parkinson’s medications and our dietary supplement AtremoPlus to improve their quality of life.
During clinical trials, a gradual reduction of 25–50% in synthetic L-Dopa was achieved, along with a decrease in side effects. This transition was made possible thanks to the precise standardization of AtremoPlus in L-Dopa, enabling accurate calculation of the L-Dopa content in each scoop.
We have detailed information on this topic specifically intended for healthcare professionals. This data can be provided upon request by a healthcare professional via email at contact@atremoplus.com..
III. Differences in L-Dopa Metabolism and Pharmacogenetic Profiles
A study published in Brain by Moreau et al. highlights that, after 50 years of using L-Dopa to treat Parkinson’s disease, there are still no universal guidelines for determining the optimal dose. The usual practice involves starting with a low dose, observing effects, and adjusting according to individual responses. This lack of guidelines is partly due to pharmacogenetic variations and digestive characteristics influencing L-Dopa’s effects.
Pharmacogenetics and its Impact
Pharmacogenetics studies how genetic variations influence the metabolism of active substances, such as L-Dopa. These variations affect the production, transport, and use of dopamine in the brain, impacting the effects experienced after taking L-Dopa.
The genes influencing L-Dopa metabolism can be grouped into four categories:
- Pathogenic genes: Affect dopamine utilization, reducing its efficacy.
- Mechanical genes: Influence the enzymes converting L-Dopa into dopamine.
- Metabolic genes: Regulate the speed of L-Dopa degradation.
- Transporter genes: Facilitate L-Dopa crossing the blood-brain barrier.
These factors can explain why reactions to L-Dopa vary from person to person.
IV. Clinical Study on AtremoPlus: Three Response Groups
In one of the clinical studies on AtremoPlus, the results allowed to categorize participants into three groups based on their response to the supplement:
- Group 1 (16.24%): Rapid reactions, sometimes noticeable from the first dose, including among individuals who have had Parkinson’s for a long time.
- Group 2 (58.12%): Gradual results, noticeable within 1 to 4 weeks.
- Group 3 (25.64%): Slower reactions, visible over the long term.
This means that nearly 75% of participants experienced noticeable effects within the first month when taking a daily dose of 10 g of powder. Group 3 generally observes less immediate but progressively significant benefits over time.
L-Dopa Metabolization: Four Main Profiles
The study identified four types of metabolizers, describing how individuals process and utilize L-Dopa:
- Extensive Metabolizers (EM): Rapid metabolism (67% of those tested).
- Intermediate Metabolizers (IM): Moderate metabolism (25%).
- Poor Metabolizers (PM): Slow metabolism (3.5%).
- Ultra-Rapid Metabolizers (UM): Very rapid metabolism (7%).
The results indicate:
- 67% of participants metabolize L-Dopa well.
- 25% exhibit moderate metabolism.
- 3.5% have a slow metabolism, limiting perceived effects.
- 7% metabolize very rapidly, requiring dosage adjustments.
Ultra-rapid metabolizers (UM), who process L-Dopa quickly, may need to divide their daily dose of 10 g into smaller portions (e.g., 4 doses of 2.5 g) to avoid fluctuations and maintain stable dopamine levels throughout the day.
Importance of Personalized Adjustments
Each body processes L-Dopa uniquely, affecting its effectiveness. For instance, someone in Group 1 might experience significant effects with just 5 g per day, while a person in Group 2 might need 10 g to notice an even clearer improvement in quality of life. This genetic variability contributes to explains why treatment responses vary.
Role of Vicia Faba in L-Dopa Effectiveness
Vicia faba is also a natural source of Carbidopa, an essential compound that facilitates L-Dopa’s transport across the blood-brain barrier. This Carbidopa content helps overcome certain genetic limitations, optimizing L-Dopa’s effectiveness. This partly explains the positive outcomes observed in a broad range of users.
In conclusion, a standard dose of 10 g of AtremoPlus per day (equivalent to 215 mg of L-Dopa) delivers good results for the majority of users. However, personalized adjustments are essential to account for pharmacogenetic variations and maximize the benefits of supplementation.
V. The Vicious Cycle of Increasing L-Dopa Doses Over the Years
In Parkinson’s disease management, neurologists aim to maintain a stable L-Dopa/Carbidopa intake to optimize patient outcomes through precise “tuning.”
These adjustments often involve a gradual increase in synthetic L-Dopa doses due to a well-known phenomenon in the medical community: “wearing off.”
The “wearing off” phenomenon refers to the decreasing efficacy of synthetic L-Dopa over time, necessitating progressively higher dosages until reaching the maximum recommended dose of the active ingredient, as specified by specialized references like Vidal in France or its international equivalents.
In contrast, with AtremoPlus—though each case is unique—clients frequently report noticeable improvements within the first weeks, followed by continuous progress over 12 to 18 months, and ultimately long-term stability without requiring dosage increases. Moreover, no reduction in the efficacy of the L-Dopa/Carbidopa in AtremoPlus has been observed over time.
In this context, many neurologists are often pleasantly surprised by the long-term stability of their patients using AtremoPlus, without the need for regular increases in synthetic doses.
VI. Irregular Consumption Based on Stress, Physical Activity, and Mental Activity
Although our bodies operate on relatively consistent pharmacogenetic foundations (as discussed in Chapter 3 above), they are also influenced by a multitude of variables that affect our daily needs, including those for L-Dopa, often in unpredictable ways.
This phenomenon explains why an “optimal dosage” that works well one day may become ineffective the next and then work again the following day, even in individuals whose lifestyles seem relatively stable.
Every day is unique, with its own challenges and dynamics, leading to significant fluctuations. It’s comparable to driving the same 100 km distance under different conditions. Fuel consumption will vary depending on whether it’s a winding mountain road, a city route with frequent stops, a highway at 120 km/h, or driving at 160 km/h.
Similarly, our dopamine consumption is not linear. It depends on a complex combination of physiological, environmental, and emotional factors, all of which can vary. This variability sometimes makes anticipating and stabilizing L-Dopa requirements difficult, emphasizing the importance of adapting to each situation. Ideally, we would be able to precisely measure L-Dopa and dopamine levels in the brain to adjust intake optimally. Unfortunately, we do not (yet) have access to such data, making it crucial to observe and listen to how we feel.
Here are the main processes and factors that can cause variations in dopamine requirements, affecting its usage or production in the brain:
1) Stress
- Chronic stress activates the hypothalamic-pituitary-adrenal (HPA) axis, increasing cortisol release.
- Cortisol can:
– Reduce dopamine availability in the brain.
– Increase fluctuations in dopaminergic response, making dopamine needs more variable. - Acute stress can also increase dopamine requirements, and therefore the precursor L-Dopa.
- Physical effort, particularly intense exercise, stimulates dopamine production but also increases its consumption to support motor and cognitive functions.
- Moderate to intense exercise may release dopamine in the brain but requires more dopamine precursors to maintain balance.
3) Sleep
- Sleep deprivation or poor-quality sleep reduces dopamine levels in the brain, particularly in regions responsible for alertness.
- This can temporarily increase dopamine needs to compensate for deficits related to fatigue and attention.
4) Diet
- Nutritional deficiencies: A diet low in dopamine precursors (e.g., L-Dopa, tyrosine, or phenylalanine) or cofactors necessary for its synthesis (iron, vitamins B6, B9, B12) can increase dopamine needs.
- Refined sugars: Glycemic spikes trigger rapid dopamine release followed by a drop, increasing requirements to maintain emotional and energy balance.
5) Intense Mental Activity
- Tasks requiring high levels of concentration, rapid decision-making, or problem-solving increase dopamine consumption.
- Prolonged intellectual work during the day can deplete dopamine reserves, necessitating increased production.
6) Emotional Variations
- Strong emotions (positive or negative) activate the dopaminergic system to regulate mood and behavioral responses.
- Intense emotional periods, excitement, anxiety, or depression can disrupt dopaminergic balance.
7) Hormonal Changes
- Hormonal fluctuations (e.g., during the menstrual cycle or menopause) can influence dopamine levels.
- Estrogen, for instance, plays a role in dopamine release regulation, and decreased estrogen levels can increase dopamine needs.
8) Environment
- Excessive environmental stimulation (screens, sounds, lights, multitasking) can increase dopamine consumption to manage associated motor and cognitive responses.
- Conversely, a low-stimulation environment can reduce dopamine release.
9) Gut Microbiota Imbalances
- The microbiota indirectly influences dopamine production and regulation.
- Dysbiosis (imbalance in gut bacteria) can increase dopamine needs by reducing its efficiency or availability.
Thus, the challenges of each day vary constantly: an important meeting, a visit from grandchildren, an outing with friends, or the stress of an event. Personal tensions or anxiety-inducing news can amplify worry. There are also mornings when one feels inexplicably exhausted upon waking, making even simple tasks seem heavier.
All these situations affect our daily dopamine needs, which fluctuate depending on emotions, activities, and context. Every factor becomes a new variable in determining the right dosage.
VII. Finding Your Best Way to Take AtremoPlus
The true challenge in managing L-Dopa/Carbidopa intake lies in finding your optimal dosage—not just based on your constitutional needs but also considering the unique demands and challenges of each day.
Many users report finding a good baseline dosage while making slight adjustments to their AtremoPlus intake based on their daily needs. They typically follow a standard dosage but occasionally add an extra scoop for specific situations: important meetings, outings, significant events, or periods of fatigue and stress. This personalized approach allows them to better manage daily fluctuations and respond more effectively to the moment’s demands.
As living beings—not machines—it is often beneficial to listen to your body, pay attention to its signals, and remain attuned to the variations in its needs throughout the day.
During the initial introduction phase of AtremoPlus, it is essential to establish your baseline. Over time, this routine will likely prove well-suited to most of your days. However, you may eventually discover with satisfaction how small adjustments can make AtremoPlus a true ally in optimizing your daily life.
Of course, these adjustments must always respect the recommended daily limits for L-Dopa to ensure safety and efficacy.
To conclude, we want to emphasize that this newsletter is not intended to provide medical advice, as only healthcare professionals are qualified to do so. For any medical questions, we encourage you to consult your healthcare provider.
The goal of these explanations is primarily educational, to better understand the various mechanisms that may impact AtremoPlus dosage.
We are, of course, here to help you determine the best dosage of AtremoPlus if you have individual questions.
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Disclaimer:
Please note that this blog provides information about our AtremoPlus supplement and related topics.
This blog is not intended to provide medical advice. If you have medical questions, please consult your healthcare professional.