AtremoPlus: Norepinephrine, an Essential but Overlooked Element in the Fight Against Parkinson’s!

What is a neurotransmitter, really?

To begin with, it would be interesting to clarify what exactly a neurotransmitter is, making the term less abstract:

It is simply a molecule that transmits signals from one neuron to another, playing a crucial role in communication within the nervous system. Each neurotransmitter acts as a messenger with various missions: some send orders to activate muscles, others transmit feelings of well-being, while others provide instructions to stay focused, memorize information, or digest a meal. Without these messengers, our bodies would be immobilized, unable to coordinate their actions.

But what are the specific missions of norepinephrine that impact those affected by Parkinson’s so significantly?

Section 1: Norepinephrine and Cognitive Function
Norepinephrine plays a key role in memory, concentration, and overall cognitive functions. With age, these abilities naturally decline, but people with Parkinson’s may face a more rapid deterioration. The term cognitive functions is used to encompass essential mental processes such as thinking, remembering, and learning. Norepinephrine allows these processes to remain effective. A lack of norepinephrine can lead to difficulties in maintaining attention, slowing information processing, and thus decision-making, as well as memory issues. By increasing its production, one can observe an improvement in mental clarity and alertness.

Section 2: Mood and Emotional Resilience
Norepinephrine is also known for its positive influence on mood. It is often referred to as a “mood booster,” promoting a more positive attitude and better emotional resilience. For individuals with Parkinson’s, maintaining a positive attitude can be challenging, as the disease often leads to mood disorders and emotional issues, including difficulties waking up, sleep disturbances, dreams and nightmares, as well as chronic stress. This is where norepinephrine comes into play, regulating mood and fostering a sense of well-being. Numerous studies around the world have shown that an increase in norepinephrine can help reduce issues such as depression and anxiety, which are common among people suffering from Parkinson’s.

Section 3: Norepinephrine and Energy
As we age, energy tends to decrease, making it difficult to initiate actions. This lack of energy is even more pronounced in people with Parkinson’s. Norepinephrine plays a crucial role in triggering movement and maintaining energy levels. It is involved in the “fight-or-flight” response, providing the energy and motivation necessary to engage with the world around us. Many users of AtremoPlus report a boost in energy and vitality, helping them overcome episodes of “freezing” or periods of inactivity, and giving them the impetus to reconnect with the world.

Section 4: Norepinephrine and Motor Functions
An often-overlooked aspect of norepinephrine is its role in motor functions. While dopamine is traditionally viewed as the primary neurotransmitter involved in movement, research shows that norepinephrine also plays a role in motor coordination. A deficiency in norepinephrine can lead to slowness, poor coordination, and difficulties with fine movements—issues often observed in people with Parkinson’s. By increasing norepinephrine levels, individuals with Parkinson’s may see an improvement in their overall motor skills, including better coordination and movement control.

Furthermore, science highlights the neuroprotective properties of norepinephrine

After exploring the role of this neurotransmitter in our bodies and the areas it influences, we will now focus on another aspect that places norepinephrine among the essential components to consider for improving the quality of life for people with Parkinson’s. Indeed, recent research reveals that norepinephrine plays a crucial role in neuroprotection by acting through various mechanisms. It is involved in modulating the stress response and regulating inflammation—two factors often exacerbated in individuals with Parkinson’s. Studies show that norepinephrine helps reduce oxidative damage by activating signaling pathways that promote neuronal survival and inhibit apoptosis. It also aids in maintaining neuronal homeostasis, meaning the balance and stability of neuronal functions, by modulating neurotransmitter release and supporting synaptic plasticity. You will find several studies on this topic in the appendix.
 

Conclusion:

Many clients report feeling more connected to themselves, more easily initiating physical and mental movements. Tasks that were once laborious become more accessible, and the desire to reconnect with friends or engage socially is rekindled. It is highly likely that the activation of norepinephrine circuits significantly contributes to these improvements. With an average increase of 26% in norepinephrine levels after taking AtremoPlus, it is not surprising that users experience a significant enhancement in their well-being and quality of life.

Scientific References Demonstrating the Importance of Norepinephrine:

An increasing number of recent studies from scientific teams worldwide have highlighted the importance of norepinephrine in managing Parkinson’s disease. Below is a brief excerpt with some interesting references:

1. Wang, Q., Song, S., Jiang, L., & Hong, J. S. (2021). Interplay among norepinephrine, NOX2, and neuroinflammation: key players in Parkinson’s disease and prime targets for therapies. Ageing Neur Dis, 1(6).

The study by Wang et al. (2021) explores the interaction between norepinephrine and neuroinflammation in the context of Parkinson’s. The authors emphasize that these elements play a crucial role in the progression of the disease, highlighting their potential as therapeutic targets for the development of new treatments. By analyzing these mechanisms, the study paves the way for innovative approaches to mitigate neurogenic inflammation and improve clinical outcomes in people with Parkinson’s.

2. Song, S., Jiang, L., Oyarzabal, E. A., Wilson, B., Li, Z., Shih, Y. Y. I., … & Hong, J. S. (2019). Loss of brain norepinephrine elicits neuroinflammation-mediated oxidative injury and selective caudo-rostral neurodegeneration. Molecular neurobiology, 56, 2653-2669.

The study demonstrates that the loss of norepinephrine in the brain triggers neurogenic inflammation leading to oxidative injury and selective neurodegeneration. The findings highlight the critical role of norepinephrine in neuronal protection and suggest that its decline may contribute to the progression of neurodegenerative disorders, such as Parkinson’s disease. This research underscores the importance of exploring therapeutic strategies aimed at restoring norepinephrine levels to mitigate these harmful effects.

3. Cui, K., Yang, F., Tufan, T., Raza, M. U., Zhan, Y., Fan, Y., … & Zhu, M. Y. (2021). Restoration of noradrenergic function in Parkinson’s disease model mice. ASN neuro, 13, 17590914211009730.

The study explores the restoration of noradrenergic function in mice models of Parkinson’s disease. The researchers observed that restoring this function leads to improvements in motor symptoms and a reduction in neurogenic inflammation. These results suggest that restoring noradrenergic signaling could be a promising strategy to mitigate the manifestations of Parkinson’s disease and potentially improve patients’ quality of life.

4. Bari, B. A., Chokshi, V., & Schmidt, K. (2020). Locus coeruleus-norepinephrine: basic functions and insights into Parkinson’s disease. Neural regeneration research, 15(6), 1006-1013.

This article examines the essential role of norepinephrine in normal brain function and its involvement in Parkinson’s disease. The authors highlight that the degeneration of noradrenergic neurons contributes to various motor and non-motor issues associated with the disease. By better understanding these mechanisms, the study opens avenues for therapies targeting the noradrenergic pathway, thus offering new possibilities for improving management of issues in individuals with Parkinson’s.

As always, it is essential to continue research in this direction, but current results are already very promising, indicating that norepinephrine plays an essential and certainly underestimated role in Parkinson’s disease. It is clear that this therapeutic pathway remains largely underutilized to better understand and manage Parkinson’s.

We are therefore particularly excited that our scientific teams’ work has highlighted such a significant increase in norepinephrine following the intake of AtremoPlus.